Processes leading to the alteration of isotopeAtoms of the same atomic number (i.e. the same chemical elem... composition in a substance, e.g.: H2S + HDO => HDS + H2O (H = “normal” hydrogen, D = deuteriumHydrogen isotope with a nucleus containing a neutron and a p..., “heavy” hydrogen, S = sulphur). The equilibrium is influenced by the different relative atomic masses.